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Time-restricted eating affects human adipose tissue fat mobilization

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dc.contributor.authorZambrano, Carolina
dc.contributor.authorGonzález-Alvarado, Elena
dc.contributor.authorSalmerón Martínez, Diego
dc.contributor.authorRuiz-Ojeda, Francisco Javier
dc.contributor.authorLuján, Juan
dc.contributor.authorScheer, Frank A.J.L.
dc.contributor.authorGaraulet, Marta
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-10-25T06:51:42Z
dc.date.available2024-10-25T06:51:42Z
dc.date.issued2024-07-28
dc.description© 2024 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Obesity. To access the final edited and published work see https://doi.org/10.1002/oby.24057es
dc.description.abstractObjective: Time-restricted eating (TRE), a dietary approach that confines food intake to specific time windows, has shown metabolic benefits. However, its impact on body weight loss remains inconclusive. The objective of this study was to investigate the influence of early TRE (eTRE) and delayed TRE (dTRE) on fat mobilization using human adipose tissue (AT) cultures. Methods: Subcutaneous AT was collected from 21 participants with severe obesity. We assessed fat mobilization by measuring glycerol release in AT culture across four treatment conditions: control, eTRE, dTRE, and 24-h fasting. Results: TRE had a significant impact on lipolysis (glycerol release [mean (SD)] in micromoles per hour per gram: control, 0.05 [0.003]; eTRE, 0.10 [0.006]; dTRE, 0.08 [0.005]; and fasting, 0.17 [0.008]; p < 0.0001). Both eTRE and dTRE increased lipolysis compared with the control group, with eTRE showing higher glycerol mobilization than dTRE during the overall 24-h time window, especially at the nighttime/habitual sleep episode (p < 0.0001). Further analysis of TRE based on fasting duration revealed that, independently of the time window, glycerol release increased with fasting duration (in micromoles per hour per gram: 8 h = 0.08 [0.001]; 12 h = 0.09 [0.008]; and 16 h of fasting = 0.12 [0.011]; p < 0.0001). Conclusions: This study provides insights into the potential benefits of TRE on fat mobilization and may guide the design of future dietary strategies for weight man agement and metabolic health.es
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dc.identifier.citationObesity (Silver Spring). 2024 32:1680‐1688
dc.identifier.doihttps://doi.org/10.1002/oby.24057
dc.identifier.issnPrint: 1930-7381
dc.identifier.issnElectronic: 1930-739X
dc.identifier.urihttp://hdl.handle.net/10201/145729
dc.languageenges
dc.publisherWileyes
dc.relationThis work has been supported in part by grant PID2020 112768RB-I00 funded by Ministerio de Ciencia, Innovacion y Universidades/Agencia estatal de investigación (MCIN/AEI)/10.13039/501100011033 to Marta Garaulet and by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK105072 to Marta Garaulet. Frank A. J. L. Scheer was supported in part by NIDDK R01DK105072 and National Heart, Lung, and Blood Institute (NHLBI) R01HL140574.es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/oby.24057
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleTime-restricted eating affects human adipose tissue fat mobilizationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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