Publication: Time-restricted eating affects human adipose tissue fat mobilization
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Date
2024-07-28
Authors
Zambrano, Carolina ; González-Alvarado, Elena ; Salmerón Martínez, Diego ; Ruiz-Ojeda, Francisco Javier ; Luján, Juan ; Scheer, Frank A.J.L. ; Garaulet, Marta
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Publisher
Wiley
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DOI
https://doi.org/10.1002/oby.24057
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info:eu-repo/semantics/article
Description
© 2024 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Obesity. To access the final edited and published work see https://doi.org/10.1002/oby.24057
Abstract
Objective: Time-restricted eating (TRE), a dietary approach that confines food intake to specific time windows, has shown metabolic benefits. However, its impact on body weight loss remains inconclusive. The objective of this study was to investigate the influence of early TRE (eTRE) and delayed TRE (dTRE) on fat mobilization using human adipose tissue (AT) cultures. Methods: Subcutaneous AT was collected from 21 participants with severe obesity. We assessed fat mobilization by measuring glycerol release in AT culture across four
treatment conditions: control, eTRE, dTRE, and 24-h fasting. Results: TRE had a significant impact on lipolysis (glycerol release [mean (SD)] in micromoles per hour per gram: control, 0.05 [0.003]; eTRE, 0.10 [0.006]; dTRE, 0.08 [0.005]; and fasting, 0.17 [0.008]; p < 0.0001). Both eTRE and dTRE increased lipolysis compared with the control group, with eTRE showing higher glycerol mobilization than dTRE during the overall 24-h time window, especially at the nighttime/habitual sleep episode (p < 0.0001). Further analysis of TRE based on fasting duration revealed that, independently of the time window, glycerol release increased with fasting duration (in micromoles per hour per gram: 8 h = 0.08 [0.001]; 12 h = 0.09 [0.008]; and 16 h of fasting = 0.12 [0.011]; p < 0.0001). Conclusions: This study provides insights into the potential benefits of TRE on fat mobilization and may guide the design of future dietary strategies for weight man agement and metabolic health.
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Citation
Obesity (Silver Spring). 2024 32:1680‐1688
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