Publication: Pancreatic duct infiltration in the low-dose streptozocin-treated mouse
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Date
1994
Authors
Papaccio, G. ; Strate, C. ; Linn, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The pancreatic-duct system was observed
during the initial stage of type 1 diabetes in C57BLI6J
mice rendered diabetic with low doses of streptozocin.
Light microscopy revealed that the ducts located in close
proximity to islets (islet ducts) were involved in the
infiltrating process: inflammatory cells extended from
the islets to these ducts. However, ducts that were
located far from islets (non-islet ducts) were generally
free from infiltration. Immunocytochemistry revealed
that both islet ducts and non-islet ducts express MHC
class I1 and ICAM-l molecules: this positivity seems to
be mainly expressed by elements infiltrating the
connective layer or by endothelia of vessels surrounding
ducts. Strong ICAM-l positivity demonstrates that
adhesiveness is widely represented in early diabetes in
this animal model. At the ultrastructural level only a few
endocrine elements were observed scattered within the
epithelia1 layer and single infiltrating elements were
rarely encountered within the connective layer of ducts.
The existence of other sites of ccactivation>>o ther than
the islets of Langerhans, in this as well as in other
animal models of types 1 diabetes, is consistent with the
hypothesis of an initially more widespread and less
specific process that later undergoes restriction.
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