Publication: Heparanase and heparanase 2 display differently deregulation in neuroendocrine tumors, depending on their differentiation grade
Authors
García, Beatriz ; García-Suárez, Olivia ; Fernández-Vega, Iván ; Vallina, Aitana ; Astudillo, Aurora ; Quirós, Luis M.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-650
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info:eu-repo/semantics/article
Description
Abstract
Heparanase is a glucuronidase that appears
upregulated in many human cancers and is involved in
cellular invasion and tumor metastasis. Heparanase 2 is a
homologue of heparanase that lacks enzymatic activity
and displays anti-metastatic features. The aim of this
work was to analyze the expression of both molecules in
neuroendocrine tumors. We investigated the
transcription of heparanases in lung neuroendocrine
tumors well- and poorly differentiated using RT-PCR,
and the expresion of the proteins by means of
immunohistochemistry. The tumors were selected
according to different malignancy WHO 2013 grades
and were arranged in tissue arrays. The prometastatic
enzyme heparanase appeared overexpressed in well- but
not in poorly differentiated tumors, irrespective of their
location. Moreover, the anti-metastatic heparanase 2
increased its expression in well-differentiated tumors,
but strongly decreased in poorly differentiated ones,
again independently of anatomic origin. Given the
involvement of both molecules in tumor progression,
through both their catalytic and non-enzymatic
properties, there would seem to be a relationship
between the regulation of their expression and the
features of the neuroendocrine tumor.
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Citation
Histology and Histopathology, vol.31, nº 1, (2016)
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