Publication: Effects of melatonin, testosterone and the two hormones
administered in parallel on ventral prostate
of the rat treated with stilbestrol in the first day of life
Authors
Limanowski, A. ; Miskowiak, B. ; Otulakowski, B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Effects of melatonin, testosterone and the
two hormones administered in parallel on ventral
prostate were examined in the rats treated with estrogens
in the first day of life. Thirty-nine-day long hormonal
stimulation with melatonin, testosterone or the two
hormones in parallel was started in rats aged 20, 28, 35
or 45 days. A single dose of estrogens led to atrophy of
ventral prostate when the animals reached maturity,
which was associated with high LH levels and low
testosterone levels in the serum. Melatonin accentuated
estrogen-induced changes in prostate morphology of
ventral prostate while initemporal administration of
melatonin and testosterone led to a resultant effect of
testosterone-induced stimulation and melatonin-induced
inhibition.
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Citation
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