Publication: Immunohistochemical analysis of steroid receptors in ovaries of postmenopausal women - effects of aging and hormone status
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Date
2010
Authors
Brodowska, A. ; Laszczynska, M. ; Starczewski, A. ; Brodowski, J. ; Masiuk, M. ; Domagała, W.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Current knowledge on immunolocalization
and immunoexpression of steroid hormone receptors,
especially estrogen receptor alpha (ER-α), progesterone
receptor (PR) and androgen receptor (AR) in normal
ovaries in postmenopausal women is not complete. The
recognition of localization of these receptors in
postmenopausal women is crucial, as many of these
women receive estro-progestagene therapy, and its
participation in the pathogenesis of ovarian cancer
should be carefully studied. In our paper we present the
results of immunohistochemical studies performed on
samples from 100 post-menopausal women (aged: 48 to
60 years) who did not use hormonal therapy. The ovaries
were removed during elective operation due to uterine
leiomyoma, endometriosis and/or prolapsed uterine. PR,
ER-α and AR were detected in the normal ovaries of
postmenopausal women in stroma and in ovarian surface
epithelium, as well as in its invagination and in epithelial
inclusion cysts. The expression of PR and AR did not
change, while the expression of ER-α decreased in time
from menopause, and it was also detected in patients
more than 10 years after menopause. Women older than
60 were not included in the study. The concentration of
selected hormones was measured in the serum. The
immunohistochemical expression of PR and AR were
similar in all examined patients and did not correlate
with FSH, LH, T, A, DHEAS concentrations in serum,
while immunohistochemical expression of ER-α
correlated with FSH, LH, T, A, DHEAS concentrations
in serum. The significant correlation of decreasing
expression of ER-α in normal ovarian tissue and decreasing concentrations of T, A and DHEAS in serum
were found, as well as increasing serum concentrations
of FSH and LH.
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