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New potential biomarkers of oxidative stress in Mytilus galloprovincialis: Analytical validation and overlap performance

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dc.contributor.authorFranco-Martínez, Lorena
dc.contributor.authorRomero, Diego
dc.contributor.authorPeres Rubio, Camila
dc.contributor.authorTecles, Fernando
dc.contributor.authorMartínez-Subiela, Silvia
dc.contributor.authorTeles, Mariana
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-03-13T07:47:34Z
dc.date.available2024-03-13T07:47:34Z
dc.date.issued2018-04-23
dc.description© 2018 Elsevier Inc. All rights reserved. This document is the Published version of a Published Work that appeared in final form in Comparative Biochemistry and Physiology, Part B. To access the final edited and published work see https://doi.org/10.1016/j.cbpb.2018.04.006es
dc.description.abstractThe aim of the present report was to develop and validate new automated spectrophotometric assays for measurement of total antioxidant capacity (TAC), thiols, and advanced oxidation protein products (AOPP) in mussel gills, digestive gland and hemolymph samples, and to evaluate their possible utility in biomonitoring programs. Total antioxidant capacity (TAC) was measured by different methods: trolox equivalent antioxidant capacity (TEAC1 and TEAC2), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing ability of plasma (FRAP). The assays were precise, accurate and provided low limits of detection. When oxidative stress was promoted by inducing hypoxia and the behaviour of these biomarkers between hypoxic and controls mussels were compared, statistically significant differences were observed in all biomarkers and tissues evaluated. The results of the present study demonstrated that these biomarkers, not previously studied in mussels, show a potential use as biomarkers of oxidative stress in this species since they were validated and showed changes under a state of oxidative stress.es
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dc.format.extent6es
dc.identifier.citationComparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. Volumes 221–222, July 2018, Pages 44-49
dc.identifier.doihttps://doi.org/10.1016/j.cbpb.2018.04.006
dc.identifier.issnPrint: 1096-4959
dc.identifier.issnElectronic: 1879-1107
dc.identifier.urihttp://hdl.handle.net/10201/140159
dc.languageenges
dc.publisherElsevieres
dc.relationPredoctoral contract “FPU” of the University of Murcia, Spain; The National Council for Scientific and Technological development (CNPq) of Brazil funded the PhD scholarship of CPR. MT has a post-doctoral fellowship from FCT (SFRH/BPD/109219/2015) supported by the European Social Fund and national funds from the “Ministério da Educação e Ciência (POPH–QREN–Tipologia 4.1)” of Portugal; Post-doctoral fellowshisp “Juan de la Cierva Incorporacion” supported by the “Ministerio de Economía yCompetitividad” (IJCI-2015-26301), Spain.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1096495918300484?via%3Dihubes
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAntioxidantses
dc.subjectAssay validationes
dc.subjectHypoxiaes
dc.subjectMusselses
dc.subjectNovel biomarkerses
dc.subjectOxidantses
dc.subjectOxidative stresses
dc.titleNew potential biomarkers of oxidative stress in Mytilus galloprovincialis: Analytical validation and overlap performancees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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