The effect of corticotropin-releasing hormone (CRH)
on the adrenal medulla in hypophysectomized rats

Hoheisel, G.; Schauer, J.; Scherbaum, W. A.; Bornstein, S. R.

Publication:
The effect of corticotropin-releasing hormone (CRH) on the adrenal medulla in hypophysectomized rats

dc.contributor.author	Hoheisel, G.
dc.contributor.author	Schauer, J.
dc.contributor.author	Scherbaum, W. A.
dc.contributor.author	Bornstein, S. R.
dc.date.accessioned	2020-05-21T16:32:30Z
dc.date.available	2020-05-21T16:32:30Z
dc.date.issued	1998
dc.description.abstract	CRH occurs in the adrenal medulla of rats. We were interested to know whether CRH affects medullary chromaffin cells in the absence of ACTH. We investigated the morphological changes of the adrenal medulla in Sprague Dawley rats with light and electron microscopy in normal rats, hypophysectomized rats, and hypophysectomized rats following injections of CRH (10 Jig = 3 nmol for three days). Chromaffin cells were characterized by immunohistochemistry (anti-tyrosine hydroxylase). At light microscopy level chromaffin cells of hypophysectomized rats were reduced in number. On electron microscopy the number of granules and cell organelles were decreased. Following injections of CRH the medulla regained a more compact texture with cell organelles homogenously distributed, but with chromaffin granules still being reduced in number. Immunohistochemistry allowed the identification of chromaffin cells located within the adrenal cortex. In hypophysectomized rats these cells showed fewer signs of alterations compared to cells located within the medulla itself and had recovered better after treatment with CRH. In conclusion. CRH seems to exert a trophic effect on chromaffin cells in the absence of pituitary ACTH. This observation may provide further evidence for a close interaction of the two neuroendocrine stress systems.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.citation	Histology and histopathology, Vol. 13, nº 1 (1998)
dc.identifier.issn	0213-3911
dc.identifier.issn	1699-5848
dc.identifier.uri	http://hdl.handle.net/10201/92481
dc.language	eng	es
dc.publisher	Histology and histopathology, Vol.13, nº 1 (1998)	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Corticotropin-releasing hormone (CRH)	es
dc.subject	Hypophysectomy	es
dc.subject	Adrenal medulla	es
dc.subject	Rat (Sprague Dawley)	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	The effect of corticotropin-releasing hormone (CRH) on the adrenal medulla in hypophysectomized rats	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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