Publication: The effect of corticotropin-releasing hormone (CRH)
on the adrenal medulla in hypophysectomized rats
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Date
1998
Authors
Hoheisel, G. ; Schauer, J. ; Scherbaum, W. A. ; Bornstein, S. R.
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Publisher
Histology and histopathology, Vol.13, nÂș 1 (1998)
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DOI
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info:eu-repo/semantics/article
Description
Abstract
CRH occurs in the adrenal medulla of rats.
We were interested to know whether CRH affects
medullary chromaffin cells in the absence of ACTH. We
investigated the morphological changes of the adrenal
medulla in Sprague Dawley rats with light and electron
microscopy in normal rats, hypophysectomized rats, and
hypophysectomized rats following injections of CRH
(10 Jig = 3 nmol for three days). Chromaffin cells were
characterized by immunohistochemistry (anti-tyrosine
hydroxylase). At light microscopy level chromaffin cells
of hypophysectomized rats were reduced in number. On
electron microscopy the number of granules and cell
organelles were decreased. Following injections of CRH
the medulla regained a more compact texture with cell
organelles homogenously distributed, but with
chromaffin granules still being reduced in number.
Immunohistochemistry allowed the identification of
chromaffin cells located within the adrenal cortex. In
hypophysectomized rats these cells showed fewer signs
of alterations compared to cells located within the
medulla itself and had recovered better after treatment
with CRH. In conclusion. CRH seems to exert a trophic
effect on chromaffin cells in the absence of pituitary
ACTH. This observation may provide further evidence
for a close interaction of the two neuroendocrine stress
systems.
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Citation
Histology and histopathology, Vol. 13, nÂș 1 (1998)
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