Publication: Proliferation indices and p53-immunocytochemistry in uterine mixed mullerian tumors
Authors
Nicòtina, P.A. ; Ferlazzo, G. ; Vincelli, A.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mixed mullerian tumor (MMT) is a biphasic
malignancy of elderly women. It, including both a
carcinomatous and a sarcomatous component (CC and
SC), is regarded as a female genital tract carcinosarcoma
(FGTCS). Since current methods to grade CC and SC
are not still univocal, the authors estimate mitotic index
(MI) and MIB 1-immunolabeling index (MIB 1-LI) as
common prognostic indices for the MMT components.
They also compare above prognostic indices with p-53
immunocytochernistry, in MMTs. The present study thus
points out that: (a) MI of CC and SC areas is consistent
with the respective conventional tumor grades; (b) MI
averages of CC are higher than those observed in the SC
areas; (c) MI and MIB 1-LI of the CC-tumor cells
correlate reciprocally in a very significant fashion; (d) A
diffuse strong p53 nuclear immunostaining (SO% cells)
is often patent where the highest MI and MIB 1-LI are
found. In conclusion, the authors propose MI and MIB
1-LI as two complementary useful indices to assess
prognosis of MMTs. They also suggest p53 nuclear
immunolabeling should be regarded as an independent
biomarker of unfavourable MMT behaviour.
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