Publication: Dermal cylindroma. Expression of intermediate filaments, epithelial and neuroectodermal antigens
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Date
1992
Authors
Wollina, Uwe ; Rülke, D. ; Schaarschmidt, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We report on irnmunohistochemical staining
pattems in so-called apocrine tumors of skin with special
emphasis on the dermal cylindroma. The results
were compared with apocrine tubular adenoma,
syringocystadenoma papilliferum and the normal eccrine
sweat gland.
A relationship of dermal cylindroma to the apocrine
gland is suggested by expression of lysozyme and
alphal-antichymotrypsin. The tumor shares keratin,
epithelial membrane antigen (EMA) and EGF-receptor
expresssion with eccrine and apocrine glands. The
presence of intermingled cells with a coexpression of
keratin and vimentin argues for a partial myoepithelialike
differentiation. Neuroectodermal antigens are
rnissing.
Therefore, dermal cylindroma is classified as an
adnexal tumor of skin with a variable rate of cells of
apocrine secretory, myoepithelial and undifferentiated
phenotypes
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