Publication: Lectin binding in the human foetal testis
Authors
Gheri, G. ; Vannelli, G.B. ; Marini, M. ; Zappoli Thyrion, G.D. ; Sgambati, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the present study we have investigated the
oligosaccharidic content of the glycoconjugates within
the human foetal testis starting from its earliest
differentiation phase (8, 10 and 12 weeks of gestation).
To this purpose we have used a battery of six horseradish
peroxidase-labelled lectins (SBA, PNA, WGA, UEAI,
LTA and ConA). We have obtained a complete
distributional map of the sugar residues of the
glycoconjugates in the coelomic mesothelium, tunica
albuginea, pre-Sertoli cells, pre-gonocytes, Leydig cells,
basement membrane of the sex cords, interstitial tissue,
mastocytes and endothelial cells of the capillary vessels.
Since the beginning of the testis differentiation phase the
cells of the coelomic mesothelium showed a large
amount of sugar residues. In the pre-Sertoli cells and in
the pre-gonocytes a role played as structural molecules
by some oligosaccharides could be hypothesized. Dgalactose-(
ß1?3)-N-acetyl-D-galactosamine, sialic acid,
N-acetyl-D-glucosamine and a-D-mannose could be
involved in inducing and maintaining the cellular
activity of the Leydig cells.
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