Publication: Distribution of type IV collagen, laminin, nidogen and fibronectin in the haemodynamically
stressed vascular wall
Authors
kittelberger, Reinhold ; Davis, Paul F. ; Stehbens, William E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Changes in the extracellular matrix of
haemodynamically stressed blood vessel walls were
studied by immunofluorescence histochemistry in
venous-pouch aneurysms fashioned on the site of the
common carotid artery of nine sheep. Tissues from the
thickened walls of the experimental aneurysms were
examined from 11 to 98 months post-operatively for
changes in the distribution of the basement membrane
components type IV coliagen, laminin, nidogen and
fibronectin. In the younger aneurysms, there was an
increase of the basement membrane components in the
thickened area. Very little basement membrane was
detected in older aneurysms. Diffuse staining for
fibronectin was noted in aneurysms of al1 ages. Thick
deposits of basement membrane material were observed
in calcified tissues. The changes in the matrix próteins
were similar to alterations occurring dunng the development
of atherosclerosis in human vascular tissue.
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