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Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection

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dc.contributor.authorGiannelli, G.es
dc.contributor.authorAntonaci, S.es
dc.date.accessioned2011-06-30T12:00:50Z
dc.date.available2011-06-30T12:00:50Z
dc.date.issued2005
dc.description.abstractChronic C hepatitis represents a major health problem worldwide, mainly because progression of the tissue damage leads to the development of cirrhosis and hepatocellular carcinoma. In this review we discuss the molecular mechanisms underlying the development of liver fibrosis. In particular we consider some immunologic aspects that regulate the interaction between HCV and the host immune defense. Reflections are made about the roles played by the host capacity to respond to the viral infection during therapy and the consequences of the deposition of extracellular matrix (ECM) proteins leading to the development of fibrosis. The involvement of inflammatory cytokines in regulating the proteolytic remodeling of the liver and the ECM turn-over is essential for the activation of hepatic stellate cells (HSCs), that have an important role in the progression of liver fibrosis. Finally, we analyze one of the aspects involved in the activation of the HSCs, namely the proteolytic remodeling of the surrounding environment.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22520
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCytokineses
dc.subjectLymphocyteses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleImmunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infectiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 3 (2005)