Publication: Immunological and molecular aspects of
liver fibrosis in chronic hepatitis C virus infection
Authors
Giannelli, G. ; Antonaci, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Chronic C hepatitis represents a major health
problem worldwide, mainly because progression of the
tissue damage leads to the development of cirrhosis and
hepatocellular carcinoma. In this review we discuss the
molecular mechanisms underlying the development of
liver fibrosis. In particular we consider some
immunologic aspects that regulate the interaction
between HCV and the host immune defense. Reflections
are made about the roles played by the host capacity to
respond to the viral infection during therapy and the
consequences of the deposition of extracellular matrix
(ECM) proteins leading to the development of fibrosis.
The involvement of inflammatory cytokines in
regulating the proteolytic remodeling of the liver and the
ECM turn-over is essential for the activation of hepatic
stellate cells (HSCs), that have an important role in the
progression of liver fibrosis. Finally, we analyze one of
the aspects involved in the activation of the HSCs,
namely the proteolytic remodeling of the surrounding
environment.
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Citation
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