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Epiprofin-Sp6. A new player in the regulation of tooth development

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dc.contributor.authorJimenez-Rojo, Luciaes
dc.contributor.authorIbarretxe, Gaskones
dc.contributor.authorAurrekoetxea, Maitane
dc.contributor.authorde Vega, Susana
dc.contributor.authorNakamura, Takashi
dc.contributor.authorYamada, Yoshihiko
dc.contributor.authorUnda, F.
dc.date.accessioned2015-09-29T07:19:04Z
dc.date.available2015-09-29T07:19:04Z
dc.date.issued2010
dc.description.abstractOdontogenesis is governed by a complex network of intercellular signaling events between the dental epithelium and mesenchyme. This network leads to the progressive determination of tooth shape, and to the differentiation of these tissues into enamel-producing ameloblasts and dentin-producing odontoblasts respectively. Among the main signaling pathways involved in the regulation of tooth development, Bone Morphogenetic Protein (BMP), Sonic hedgehog (Shh) and Wingless-type MMTV integration site (Wnt) pathways have been reported to play significant roles. Recently, the phenotype of mice deficient in Epiprofin/Sp6 (Epfn) has been found to present striking dental abnormalities, including a complete lack of differentiated ameloblasts and consequently no enamel, highly altered molar cusp patterns and the formation of multiple supernumerary teeth. In this article, we review the interaction of Epfn with the BMP, Shh and Wnt pathways in the regulation of tooth development, based on the data obtained from the study of several genetically modified mice.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46372
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOdontogenices
dc.subjectSupernumerary teethes
dc.subject.other61 - Medicinaes
dc.titleEpiprofin-Sp6. A new player in the regulation of tooth developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25,nº12 (2010)