Publication: Epiprofin-Sp6. A new player in the regulation of tooth development
Loading...
Date
2010
Authors
Jimenez-Rojo, Lucia ; Ibarretxe, Gaskon ; Aurrekoetxea, Maitane ; de Vega, Susana ; Nakamura, Takashi ; Yamada, Yoshihiko ; Unda, F.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Odontogenesis is governed by a complex
network of intercellular signaling events between the
dental epithelium and mesenchyme. This network leads
to the progressive determination of tooth shape, and to
the differentiation of these tissues into enamel-producing
ameloblasts and dentin-producing odontoblasts
respectively. Among the main signaling pathways
involved in the regulation of tooth development, Bone
Morphogenetic Protein (BMP), Sonic hedgehog (Shh)
and Wingless-type MMTV integration site (Wnt)
pathways have been reported to play significant roles.
Recently, the phenotype of mice deficient in
Epiprofin/Sp6 (Epfn) has been found to present striking
dental abnormalities, including a complete lack of
differentiated ameloblasts and consequently no enamel,
highly altered molar cusp patterns and the formation of
multiple supernumerary teeth. In this article, we review
the interaction of Epfn with the BMP, Shh and Wnt
pathways in the regulation of tooth development, based
on the data obtained from the study of several
genetically modified mice.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.