Publication: Fibronectin expression in cancer tissues from patients undergoing radiation therapy
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Date
1993
Authors
Nishioka, A. ; Ogawal, Y. ; Inomata, T. ; Maeda, T. ; Seguchi, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fibronectin expression and distribution were
examined in cancer tissues from 19 patients with cancer
of the head and neck regions. Samples taken before and
after irradiation of approximately l0 Gy, 20 Gy or 30 Gy
were analyzed by the avidin-biotin-horseradish
peroxidase method using mouse monoclonal antibodies
against human fibronectin. The results were correlated
with the patient's prognosis after radiation therapy. No
remarkable changes in the fibronectin expression or
distribution were found between tissue specimens taken
before and after each dose of irradiation. The prognosis,
however, varied according to the degree of expression
and the distribution pattern of fibronectin. Seven patients
in which the cancer tissue was encircled by a thick
fibronectin network are still alive without recurrence
4.5-6 years after treatment, whereas 6 patients in which
fibronectin was only faintly expressed or focally
distributed died or developed recurrence soon after
treatment. The present findings den~onstrate that
fibronectin expression and distribution in cancer tissue
are intimately related to the patient's prognosis, and that
the analysis of these two parameters is applicable as a
predictive assay in radiotherapy of cancer of the head
and neck regions.
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