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Role of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration

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dc.contributor.authorHeissig, Beate
dc.contributor.authorNishida, Chiemi
dc.contributor.authorTashiro, Yoshihiko
dc.contributor.authorSato, Yayoi
dc.contributor.authorIshihara, Makoto
dc.contributor.authorOhki, Makiko
dc.contributor.authorGritli, Ismael
dc.contributor.authorRosenkvist, Jeanette
dc.contributor.authorHattori, Koichi
dc.date.accessioned2015-10-06T15:01:38Z
dc.date.available2015-10-06T15:01:38Z
dc.date.issued2010
dc.description.abstractIschemic tissue regeneration depends on neovascularization, the growth of new blood vessels. Bone marrow (BM)-derived cells, including neutrophils, have been shown to contribute to neovascularization during hind limb ischemia and inflammation. Neutrophils produce a broad array of angiogenic growth factors and proteases, which promote remodeling of arterioles into arteries through proteolytic mechanisms. Matrix metalloproteinases (MMPs) have been shown to play a role in the recruitment of neutrophils to sites of inflammation, which requires the extravascular migration of neutrophils through the extracellular matrix. Neutrophils control critical steps during angiogenesis and neutrophil-derived MMPs can promote neoangiogenesis, and collateral growth and perfusion recovery, in part by liberating vital angiogenic growth factors, including vascular endothelial growth factor-A (VEGF-A). This review focuses on the role of neutrophils as key players in the control of the angiogenic process during ischemic tissue regeneration. Aspects of neutrophil regulation, in particular regulation by its major growth factor granulocyte colonystimulating factor (G-CSF), the role of the unique, readily available, neutrophil-derived MMP-9, and the functional consequences of this MMP-9 activation for angiogenesis, such as MMP-mediated release of biologically relevant cytokines from the matrix and cell surfaces, will be discussed.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/46511
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 25, nº 6 (2010)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAngiogenesises
dc.subjectIschemiaes
dc.subject.other576 - Biología celular y subcelular. Citologíaes
dc.titleRole of neutrophil-derived matrix metalloproteinase-9 in tissue regenerationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº6 (2010)