Publication: Role of neutrophil-derived matrix
metalloproteinase-9 in tissue regeneration
Authors
Heissig, Beate ; Nishida, Chiemi ; Tashiro, Yoshihiko ; Sato, Yayoi ; Ishihara, Makoto ; Ohki, Makiko ; Gritli, Ismael ; Rosenkvist, Jeanette ; Hattori, Koichi
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ischemic tissue regeneration depends on
neovascularization, the growth of new blood vessels.
Bone marrow (BM)-derived cells, including neutrophils,
have been shown to contribute to neovascularization
during hind limb ischemia and inflammation.
Neutrophils produce a broad array of angiogenic growth
factors and proteases, which promote remodeling of
arterioles into arteries through proteolytic mechanisms.
Matrix metalloproteinases (MMPs) have been shown to
play a role in the recruitment of neutrophils to sites of
inflammation, which requires the extravascular
migration of neutrophils through the extracellular
matrix. Neutrophils control critical steps during
angiogenesis and neutrophil-derived MMPs can promote
neoangiogenesis, and collateral growth and perfusion
recovery, in part by liberating vital angiogenic growth
factors, including vascular endothelial growth factor-A
(VEGF-A). This review focuses on the role of
neutrophils as key players in the control of the
angiogenic process during ischemic tissue regeneration.
Aspects of neutrophil regulation, in particular regulation
by its major growth factor granulocyte colonystimulating
factor (G-CSF), the role of the unique,
readily available, neutrophil-derived MMP-9, and the
functional consequences of this MMP-9 activation for
angiogenesis, such as MMP-mediated release of
biologically relevant cytokines from the matrix and cell surfaces, will be discussed.
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