Publication: Nephrotoxicity of cypermethrin in rats. Histopathological aspects
Date
2020
Authors
Alalwani, Aisha D.
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/: 10.14670/HH-18-263
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info:eu-repo/semantics/article
Description
Abstract
Cypermethrin (CYP) is an important type II
pyrethroid pesticide widely used to protect crops against
pests and insect infestations. However, its toxicity is a
risk to both human health and the surrounding
environment. The present study was conducted to
investigate the nephrotoxic effect and histopathological
changes caused by cypermethrin in the kidney tissues of
adult wistar rats. In this study, 30 Wistar rats were
equally divided into three groups. G1, control animals;
G2 and G3 treated with various sub lethal doses of CYP
for 30 days as follows: G2, administered low dose
(1/100 of LD50) of CYP; G3, administered high dose
(1/50 of LD50) of CYP. The damage to different
organelles of renal proximal and distal cells was
observed using transmission electron microscopy.
Histopathological damage in kidney samples was
confirmed using morphological and histological
measures. The results showed that CYP caused
significant histopathological damage to the renal
proximal and distal tubules of treated rats. Compared to
control samples, CYP caused marked alterations in the
dimensions of nucleus, ovoid and filamentous
mitochondria of the treated cells. In conclusion,
cypermethrin is found to be toxic to mammals. It caused
marked ultrastructural damage to the renal proximal and
distal tubules of wistar rats and the intensity of
nephrotoxicity correlated with the dose of oral
administration.
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Citation
Histology and Histopathology Vol. 35, nº12 (2020)
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