Publication: Siesta behavior and genetics interact to influence obesity risk
Authors
Rodriguez-Martín, María ; Salmerón Martínez, Diego ; Dashti, Hassan S. ; Cascales, Ana Isabel ; Aragón-Alonso, Aurora ; Scheer, Frank A. J. L. ; Saxena, Richa ; Garaulet, Marta
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Publisher
Wiley
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DOI
https://doi.org/10.1002/oby.24173
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info:eu-repo/semantics/article
Description
© 2024 The Author(s). This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Obesity. To access the final edited and published work see https://doi.org/ 10.1002/oby.24173
Abstract
Objective: In this cross-sectional study, we aim to investigate the interactions between obesity, siesta behavior, and the genetic propensity for siesta in a Mediterranean population, in whom siesta is deeply rooted.
Methods: We applied a previously generated Siesta-Polygenic Score (PGS) in the ONTIME study (n = 1278). Siesta and other Mediterranean lifestyle behaviors were characterized using questionnaires. We further determined obesity grade. Secondarily, we measured weight loss during treatment as well as long-term weight-loss mainte nance. Logistic regression analyses were performed to address our aim. Results: A total of 42.4% of the population usually took siesta. A significant genetic influence on siesta propensity was found, with a higher genetic predisposition linked to taking siesta more frequently (odds ratio [OR] = 1.17, 95% CI: 1.03–1.32;
p = 0.015). Participants with a higher genetic propensity for siesta showed poorer dietary habits (p < 0.05). Among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have lower odds of having obesity (p =0.038) compared with those who do not. Similarly, in exploratory analysis, among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have higher odds of weight-loss success (p = 0.007) compared with those who do not. Conclusions: Considering the ongoing debate regarding whether siesta is beneficial or detrimental, our findings suggest that individual genetic predisposition to siesta might influence the association between siesta and health.
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Citation
Obesity (Silver Spring). 2025 33:164–176
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