Publication: Diabetic nephropathy, the modulating influence of glucose on transforming factor D production
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Date
1998
Authors
Phillips, A.O.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Diabetes in now the commonest cause of
renal failure in the western world. Furthermore the
survival of diabetic patients requiring dialysis treatment
for renal failure is far less than patients with renal failure
secondary to all other diseases. It is therefore important
to identify the factors that control the development of
progressive renal disease to allow targeted therapeutic
interventions which would have major implications both
to patient well-being and also to the provision of health
care world wide. In this review we discuss possible
metabolic consequences of hyperglycemia and their role
in the pathogenesis of diabetic nephropathy. We also
focus on the involvement of the pro-fibrotic cytokine
Transforming Growth Factor B, and contrast its role in
the pathogenesis of glomerular and tubulo-interstitial
changes seen in diabetic nephropathy.
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