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Adult stem and transit-amplifying cell location

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dc.contributor.authorDíaz-Flores Jr., L.es
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorVarela, H.
dc.contributor.authorValladares, Francisco
dc.contributor.authorÁlvarez-Argüelles, H.
dc.contributor.authorDíaz-Flores, Lucio
dc.contributor.authorMadrid Cuevas, Juan Francisco
dc.date.accessioned2011-06-30T12:03:27Z
dc.date.available2011-06-30T12:03:27Z
dc.date.issued2006
dc.description.abstractAdult stem cells (ASC) -able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue- can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be useful to regenerative medicine and tissue engineering. Transit-amplifying cells (TAC) are committed progenitors among the ASC and their terminally differentiated daughter cells. The ASC reside in a specialized physical location named niche, which constitutes a three-dimensional microenviroment where ASC and TAC are protected and controlled in their selfrenewing capacity and differentiation. The niche can be located near or far from the recruitment point, requiring a short or long-distance cellular migration, respectively. This paper briefly reviews the current status of research about ASC plasticity, transdifferentiation, fusion and functional adaptation mechanisms. Subsequently, ASC and TAC occurrence, characteristics and location have been considered in the skin, cornea, respiratory tract, teeth, gastrointestinal tract, liver, pancreas, salivary glands, kidney, breast, prostate, endometrium, mesenchyma, bone marrow, skeletal and cardiac muscle, nervous system and pituitary gland. Moreover, the role of cancer ASC has also been revised.es
dc.formatapplication/pdfes
dc.format.extent32es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22698
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectStem celles
dc.subjectTransit-amplifying cellses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleAdult stem and transit-amplifying cell locationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication773c85c2-1260-4a4d-9543-f5a615648d71
relation.isAuthorOfPublication.latestForDiscovery773c85c2-1260-4a4d-9543-f5a615648d71
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Histology and histopathology Vol.21, nº 9 (2006)