Publication: Adult stem and transit-amplifying cell location
Authors
Díaz-Flores Jr., L. ; Gutiérrez, Ricardo ; Varela, H. ; Valladares, Francisco ; Álvarez-Argüelles, H. ; Díaz-Flores, Lucio ; Madrid Cuevas, Juan Francisco
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Adult stem cells (ASC) -able to self renew
and to intervene in maintaining the structural and
functional integrity of their original tissue- can express
greater plasticity than traditionally attributed to them,
adopting functional phenotypes and expression profiles
of cells from other tissues. Therefore, they could be
useful to regenerative medicine and tissue engineering.
Transit-amplifying cells (TAC) are committed
progenitors among the ASC and their terminally
differentiated daughter cells. The ASC reside in a
specialized physical location named niche, which
constitutes a three-dimensional microenviroment where
ASC and TAC are protected and controlled in their selfrenewing
capacity and differentiation. The niche can be
located near or far from the recruitment point, requiring
a short or long-distance cellular migration, respectively.
This paper briefly reviews the current status of research
about ASC plasticity, transdifferentiation, fusion and
functional adaptation mechanisms. Subsequently, ASC
and TAC occurrence, characteristics and location have
been considered in the skin, cornea, respiratory tract,
teeth, gastrointestinal tract, liver, pancreas, salivary
glands, kidney, breast, prostate, endometrium,
mesenchyma, bone marrow, skeletal and cardiac muscle,
nervous system and pituitary gland. Moreover, the role
of cancer ASC has also been revised.
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