Publication:
Experimental change on dopaminergic neurons in striatum of Parkinson disease rats

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dc.contributor.authorChen, X.Y.es
dc.contributor.authorLi, Jianges
dc.contributor.authorQi, W.Q.
dc.contributor.authorShen, S.H.
dc.date.accessioned2012-05-21T12:11:13Z
dc.date.available2012-05-21T12:11:13Z
dc.date.issued2007
dc.description.abstractBackground: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective and progressive demise of dopaminecontaining neurons in the midbrain. In this study, we observe the expression of c-Jun in the striatum of rats with 6-hydroxydopamine (6-OHDA)-lesions after apomorphine (APO) intraperitoneal injection (ip) in substantia nigra compacta (SNc), and to study the mechanism of the rotations behavior. Design: The 6- OHDA was unilaterally injected into rat right SNC. The APO- induced abnormal rotations were investigated on the 1st, 4th, 7th, 14th, 21st days after lesion, respectively. Meanwhile dopaminergic degeneration and c-Jun expression were observed with microscope. Nissl’s body staining and immunohistochemical method (ABC) were employed to study the changes of tyrosine hydroxylase (TH) and c-Jun in DA neurons. Results: We found that the number of dopaminergic neurons decreased gradually in the lesioned site and those neurons’ electron-microscopic structure was severe damaged. There were over 75% of dopaminergic neurons lost, contralateral rotations over 7 turns per minute and c-Jun expressing in the ipsilateral striatum. Conclusion: Dopaminergic neurons deletion may be linked to upregulation of c-Jun.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27648
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectApomorphinees
dc.subjectStriatumes
dc.subject.other615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleExperimental change on dopaminergic neurons in striatum of Parkinson disease ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº10 (2007)