Publication: Experimental change on dopaminergic neurons in striatum of Parkinson disease rats
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Date
2007
Authors
Chen, X.Y. ; Li, Jiang ; Qi, W.Q. ; Shen, S.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: Parkinson’s disease (PD) is a
common neurodegenerative disorder characterized by
selective and progressive demise of dopaminecontaining
neurons in the midbrain. In this study, we
observe the expression of c-Jun in the striatum of rats
with 6-hydroxydopamine (6-OHDA)-lesions after
apomorphine (APO) intraperitoneal injection (ip) in
substantia nigra compacta (SNc), and to study the
mechanism of the rotations behavior. Design: The 6-
OHDA was unilaterally injected into rat right SNC. The
APO- induced abnormal rotations were investigated on
the 1st, 4th, 7th, 14th, 21st days after lesion, respectively.
Meanwhile dopaminergic degeneration and c-Jun
expression were observed with microscope. Nissl’s body
staining and immunohistochemical method (ABC) were
employed to study the changes of tyrosine hydroxylase
(TH) and c-Jun in DA neurons. Results: We found that
the number of dopaminergic neurons decreased
gradually in the lesioned site and those neurons’
electron-microscopic structure was severe damaged.
There were over 75% of dopaminergic neurons lost,
contralateral rotations over 7 turns per minute and c-Jun
expressing in the ipsilateral striatum. Conclusion:
Dopaminergic neurons deletion may be linked to
upregulation of c-Jun.
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