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Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases

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dc.contributor.authorMarzioni, Danielaes
dc.contributor.authorQuaranta, Alexiaes
dc.contributor.authorLorenzi, Teresa
dc.contributor.authorMorroni, Manrico
dc.contributor.authorCrescimanno, Caterina
dc.contributor.authorDe Nictolis, Michele
dc.contributor.authorToti, Paolo
dc.contributor.authorMuzzonigro, Giovanni
dc.contributor.authorBaldi, A.
dc.contributor.authorDe Luca, Antonio
dc.contributor.authorCastellucci, Mario
dc.date.accessioned2014-01-09T10:34:41Z
dc.date.available2014-01-09T10:34:41Z
dc.date.issued2009
dc.description.abstractHtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocarcinoma. The aim of the study is to investigate the expression of HtrA1 in these gestational trophoblastic diseases and evaluate whether different HtrA1 expression might be associated with increasingly severe forms of disease. We used immunohistochemistry to assess the expression of HtrA1 in normal human placenta, hydatidiform mole (partial and complete) and choriocarcinoma. In addition to that we used the western blotting technique to quantify HtrA1 immunoreaction in normal human placentas. The most striking finding of our investigation is the decrease in immunostaining of this protease with increasing severity of gestational trophoblastic disease. For instance, in partial and complete moles HtrA1 is weakly expressed in the trophoblast. Moreover, absence of immunoreaction for HtrA1 is observable in the choriocarcinoma cells. In conclusion, we suggest that HtrA1 may play an important role in the pathogenesis and progression of hydatidiform moles and choriocarcinomas, and that HtrA1 may play an important role during the normal development of the placenta, as well as in trophoblastic diseases.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37537
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPlacentaes
dc.subjectImmunohistochemistryes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº10 (2009)