Publication: Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases
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Date
2009
Authors
Marzioni, Daniela ; Quaranta, Alexia ; Lorenzi, Teresa ; Morroni, Manrico ; Crescimanno, Caterina ; De Nictolis, Michele ; Toti, Paolo ; Muzzonigro, Giovanni ; Baldi, A. ; De Luca, Antonio ; Castellucci, Mario
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
HtrA1 is a secreted protein which behaves as
a molecular chaperone at low temperatures and as a
serine protease at high temperatures. When the placenta
escapes the normal growth control mechanisms, which
are present during normal pregnancy, it may develop
trophoblastic diseases, such as hydatidiform mole and
choriocarcinoma. The aim of the study is to investigate
the expression of HtrA1 in these gestational
trophoblastic diseases and evaluate whether different
HtrA1 expression might be associated with increasingly
severe forms of disease.
We used immunohistochemistry to assess the
expression of HtrA1 in normal human placenta,
hydatidiform mole (partial and complete) and
choriocarcinoma. In addition to that we used the western
blotting technique to quantify HtrA1 immunoreaction in
normal human placentas. The most striking finding of
our investigation is the decrease in immunostaining of
this protease with increasing severity of gestational
trophoblastic disease. For instance, in partial and
complete moles HtrA1 is weakly expressed in the
trophoblast. Moreover, absence of immunoreaction for
HtrA1 is observable in the choriocarcinoma cells.
In conclusion, we suggest that HtrA1 may play an
important role in the pathogenesis and progression of
hydatidiform moles and choriocarcinomas, and that HtrA1 may play an important role during the normal
development of the placenta, as well as in trophoblastic
diseases.
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