Publication: Mixed acinar-neuroendocrine carcinoma of the pancreas: a case report and a review
Authors
Jakobsen, Mark ; Klöppel, Günter ; Detlefsen, Sönke
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-767
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info:eu-repo/semantics/article
Description
Abstract
A 62-year-old woman presented with
abdominal discomfort. Imaging studies showed a tumor
in the pancreatic tail. At contrast-enhanced CT and
macroscopy, the tumor showed cystic, solid and
hemorrhagic areas. Histologically, the tumor was wellcircumscribed and entirely encapsulated. Some of the
tumor cells in the cystic areas were reminiscent of acinar
cells, and the majority was arranged in a solid growth
pattern. Immunohistochemistry revealed >30% positivity
for chymotrypsin, chromogranin A, synaptophysin, and
CD56. The diagnosis of a mixed acinar-neuroendocrine
carcinoma (MAEC) was made. Review of the English
language literature revealed 44 previously published
cases of resected MAECs. We found that, compared to
pure acinar cell carcinoma, patients with MAEC have a
slightly higher age and are less frequently males, as the
male/female ratio was almost equal. The histogenesis of
MAEC is still controversial. Due to the small number of
cases it is at present not possible to define an evidencebased optimal treatment strategy for these patients.
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Citation
Histology and Histopathology, Vol.31, nº12, (2016)
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