Publication: Disruption of mitochondrial homeostasis in chronic kidney disease: a mini-review
Authors
Li, Qing ; Zhang, Aihua ; Xing, Changying ; Yuan, Yanggang
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-101
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info:eu-repo/semantics/article
Description
Abstract
Chronic kidney disease (CKD) is recognized
as a worldwide health problem. Progression of CKD
may lead to many serious complications, which are
associated with increased morbidity and mortality.
Presently, there is no satisfactory treatment. Thus,
targeted therapies are urgently needed. The kidneys are
second to the heart in terms of mitochondrial abundance
and oxygen consumption. Thus, it is not surprising that
mitochondrial homeostasis is absolutely essential for the
normal function of the kidney. In fact, a number of
reports indicate that mitochondria are involved in the
progression of CKD. In this review, we summarize our
current knowledge on mitochondrial homeostasis in
CKD. We also provide an update on recent
developments in the field of mitochondria-targeting
therapeutic approaches against CKD
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Citation
Histology and Histopathology, Vol.34, nÂş8, (2019)
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