Publication:
Molecular and cellular mechanisms of heterotopic ossification

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dc.contributor.authorRamirez, Diana M.
dc.contributor.authorRamirez, Melissa R.
dc.contributor.authorReginato, Anthony M.
dc.contributor.authorMedici, Damian
dc.date.accessioned2019-10-18T14:20:30Z
dc.date.available2019-10-18T14:20:30Z
dc.date.issued2014
dc.description.abstractHeterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiva (FOP), a combination of inflammation associated with minor soft tissue injuries and a hereditary genetic mutation causes massive HO that progressively worsens throughout the patients’ lifetime leading to the formation of an ectopic skeleton. An activating mutation in the BMP type I receptor ALK2 has been shown to contribute to the heterotopic lesions in FOP patients, yet recent studies have shown that other events are required to stimulate HO including activation of sensory neurons, mast cell degranulation, lymphocyte infiltration, skeletal myocyte cell death, and endothelial-mesenchymal transition (EndMT). In this review, we discuss the recent evidence and mechanistic data that describe the cellular and molecular mechanisms that give rise to heterotopic bone.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 10, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/75723
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHeterotopic ossificationes
dc.subjectHOes
dc.subjectFibrodysplasia ossificans progressivaes
dc.subjectFOPes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleMolecular and cellular mechanisms of heterotopic ossificationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº10 (2014)