Publication: Molecular and cellular
mechanisms of heterotopic ossification
Authors
Ramirez, Diana M. ; Ramirez, Melissa R. ; Reginato, Anthony M. ; Medici, Damian
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Heterotopic ossification (HO) is a
debilitating condition in which cartilage and bone forms
in soft tissues such as muscle, tendon, and ligament
causing immobility. This process is induced by
inflammation associated with traumatic injury. In an
extremely rare genetic disorder called fibrodysplasia
ossificans progessiva (FOP), a combination of
inflammation associated with minor soft tissue injuries
and a hereditary genetic mutation causes massive HO
that progressively worsens throughout the patients’
lifetime leading to the formation of an ectopic skeleton.
An activating mutation in the BMP type I receptor
ALK2 has been shown to contribute to the heterotopic
lesions in FOP patients, yet recent studies have shown
that other events are required to stimulate HO including
activation of sensory neurons, mast cell degranulation,
lymphocyte infiltration, skeletal myocyte cell death, and
endothelial-mesenchymal transition (EndMT). In this
review, we discuss the recent evidence and mechanistic
data that describe the cellular and molecular mechanisms
that give rise to heterotopic bone.
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Citation
Histology and Histopathology, vol. 29, nº 10, (2014)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/