Publication: Oral sarcomatoid squamous cell carcinoma: a retrospective study based on 14 cases
Authors
Liu, Jialiang ; Xiao, Meng ; Wang, Yan’an
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-176
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info:eu-repo/semantics/article
Description
Abstract
The treatment outcomes for oral sarcomatoid
squamous cell carcinoma (OSSCC) are far from
satisfactory in our hospital. The aim of this study was to
retrospectively summarize the OSSCC cases admitted to
our department. From 2003 to 2017, 14 patients were
hospitalized and diagnosed with OSSCC. We
summarized and analysed the medical histories,
diagnostic examinations, treatment strategies, and clinical
outcomes of the involved cases. Of the 14 cases, 8 were
located in the gingiva. The imageological diagnosis
identified the existence of a mass with an infiltrative
morphology pre-operatively. The cytopathologic features
revealed a malignant neoplasm with a mixture of
squamous cell carcinoma (SCC) components and spindle
cell neoplastic components. To confirm the diagnosis of
OSSCC, the use of the immunohistochemical markers
AE1/AE3 and Vimentin were more indicative. Complete
follow-up data were available for 12 patients, and at the
last follow-up, all 12 of the patients had died. The median
overall survival for these patients was 11.67 months
(range: 3-24 months). OSSCC patients respond poorly to
the strategies solely referring to experiences from oral
squamous cell carcinoma (OSCC) treatment. The
effective diagnosis and treatment of OSSCC at an early
stage is necessary. The treatment for OSSCC still poses a
great challenge for clinical oncologists
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Citation
Histology and Histopathology Vol. 35, nÂş4 (2020)
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