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Morphometric evidence of the regulation of the activity of LH-immunoreactive cells by corticosterone. An in vivo and in vitro study

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Morphometric evidence of the regulation of the activity of LHimmunoreactive cells by corticosterone. An in vivo and in vitro study.pdf(2.7 MB)
Date
1996
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Authors
Rubio, M. ; Carretero, J. ; Cabo, J.J. ; Santos, M. ; Vázquez, R.J. ; Vázquez, R. ; Sánchez, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study was performed to investigate the morphometric effects of the administration of corticosterone on LH-immunoreactive cells of pituitary monolayer cultures. In addition, the effect of bilateral adrenalectomy on the LH-adenohypophyseal cells was explored. In vitro administration of corticosterone induced a marked decrease in the morphometric parameters considered (cellular, cytoplasmic and nuclear areas). In vivo, bilateral adrenalectomy produced a significant increase in these parameters when compared to those obtained in normal and sham-operated animals. However, when the bilaterally adrenalectomized rats received a daily dose of corticosterone no significant changes in the morphometric parameters were found. Morphometrically, these combined in vivo-in vitro findings confirm a corticosterone-induced hypoactivity of LI4-cells together with a direct effect of this glucocorticoid on LH-adenohypophyseal cells.
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Corticosterone , Adrenalectomy
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http://hdl.handle.net/10201/18895
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Histology and histopathology Vol.11, nº 4 (1996)
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