Ubiquitinated inclusions and neuronal cell death

Publication:
Ubiquitinated inclusions and neuronal cell death

dc.contributor.author	Lang-Rollin, I.	es
dc.contributor.author	Rideout, H.J.	es
dc.contributor.author	Stefanis, L.
dc.date.accessioned	2011-06-08T09:02:39Z
dc.date.available	2011-06-08T09:02:39Z
dc.date.issued	2003
dc.description.abstract	Summary. Ubiquitinated inclusions and selective neuronal cell death are considered the pathological hallmarks of Parkinson’s disease and other neurodegenerative diseases. Recent genetic, pathological and biochemical evidence suggests that dysfunction of ubiquitin-dependent protein degradation by the proteasome might be a contributing, if not initiating factor in the pathogenesis of these diseases. In neuronal cell culture models inhibition of the proteasome leads to cell death and formation of fibrillar ubiquitin and a- synuclein-positive inclusions, thus modeling some aspects of Lewy body diseases. The processes of inclusion formation and neuronal cell death share some common mechanisms, but can also be dissociated at a certain level.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/21414
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Neurodegenerative	es
dc.subject	Apoptosis	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Ubiquitinated inclusions and neuronal cell death	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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