Publication: Ubiquitinated inclusions and neuronal cell death
Authors
Lang-Rollin, I. ; Rideout, H.J. ; Stefanis, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Ubiquitinated inclusions and selective
neuronal cell death are considered the pathological
hallmarks of Parkinson’s disease and other
neurodegenerative diseases. Recent genetic, pathological
and biochemical evidence suggests that dysfunction of
ubiquitin-dependent protein degradation by the
proteasome might be a contributing, if not initiating
factor in the pathogenesis of these diseases. In neuronal
cell culture models inhibition of the proteasome leads to
cell death and formation of fibrillar ubiquitin and a-
synuclein-positive inclusions, thus modeling some
aspects of Lewy body diseases. The processes of
inclusion formation and neuronal cell death share some
common mechanisms, but can also be dissociated at a
certain level.
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Citation
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