Publication: lntraocular neovascularization
Authors
Yoshida, A. ; Yoshida, S. ; Ishibashi, T. ; Inomata, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An important character of the eye is
transparency, so intraocular neovascularization, which is
fragile and likely to result in hemorrhage, would cause a
functional disorder of the eye and contribute to loss of
vision associated with such diseases as retinopathy of
prematurity, diabetic retinopathy, retinal vein occlusion,
and age-related macular degeneration. Recently interest
in the mechanisms of intraocular neovascularization has
increased, and the mechanisms have been gradually
elucidated using several in vitro and in vivo angiogenesis
models. Blood vessels in the eye are composed
of, and surrounded by, various types of cells that
produce multiple factors. Neovascularization is regulated
by complex interactions among these angiogenic factors,
angiostatic factors, and adhesion molecules, and some of
these angiogenesis-related molecules have also been
suggested as new targets for novel therapeutic agents of
intraocular neo-vascularization. This review focuses on
in vivo representative angiogenesis models of the
corneal pocket model and the model of oxygen-induced
retinopathy, and discusses the role of some angiogenesisrelated
factors and adhesion molecules in intraocular
neovascularization.
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