Desmosomes and disease: an update

Publication:
Desmosomes and disease: an update

dc.contributor.author	Chidgey, M.A.J.	es
dc.date.accessioned	2011-05-11T10:58:56Z
dc.date.available	2011-05-11T10:58:56Z
dc.date.issued	2002
dc.description.abstract	Desmosomes play a critical role in the maintenance of normal tissue architecture. Skin blistering can occur when desmosomal adhesion is compromised by antibodies in autoimmune diseases such as pemphigus. Inherited mutations in genes encoding desmosomal constituents can adversely affect the skin, and result in heart abnormalities. Desmosomes may have a tumour suppressor function: expression of desmosomal components is reduced in some human cancers, and desmosomal cadherins have the capacity to suppress the invasiveness of cells in culture. Transgenic animal research has provided important insights into the role of these junctions in normal epithelial morphogenesis and disease.	es
dc.format	application/pdf	es
dc.format.extent	14	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/20839
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Desmosome	es
dc.subject	Disease	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Desmosomes and disease: an update	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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