Publication: Desmosomes and disease: an update
Authors
Chidgey, M.A.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Desmosomes play a critical role in the
maintenance of normal tissue architecture. Skin
blistering can occur when desmosomal adhesion is
compromised by antibodies in autoimmune diseases
such as pemphigus. Inherited mutations in genes
encoding desmosomal constituents can adversely affect
the skin, and result in heart abnormalities. Desmosomes
may have a tumour suppressor function: expression of
desmosomal components is reduced in some human
cancers, and desmosomal cadherins have the capacity to
suppress the invasiveness of cells in culture. Transgenic
animal research has provided important insights into the
role of these junctions in normal epithelial
morphogenesis and disease.
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