Publication: Changes in the distribution of the substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the laryngeal mucosa of chronically hypoxic rats
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Date
1999
Authors
Yoshida, T. ; Matsuda, H. ; Hayashida, Y. ; Gono, Y. ; Nagahara, T. ; Kawakami, T. ; Takenaka, T. ; Tsukuda, M. ; Kusakabe, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution and abundance of substance
P (SP) and calcitonin gene-related peptide (CGRP)
immunoreactive nerve fibers in four different regions of
the laryngeal mucosa were compared between normoxic
and chronically hypoxic rats (10% O2 and 3.0-4.0% CO,
for 3 months). In the chronically hypoxic laryngeal
mucosa, the number of SP and CGRP fibers within and
just beneath the epithelium, and around the laryngeal
gland was increased in comparison with those in the
normoxic controls. Especially in the epiglottic and
arytenoid regions, the number of intraepithelial SP fibers
was increased remarkably. Most intraepithelial SP and
CGRP fibers penetrated into the epithelium to extend to
the lumina1 surface. There was no distinct difference in
the distribution and abundance of these peptidergic
fibers in the mucosa of the normoxic and chronically
hypoxic vocal cord regions. These results suggest that
the increased density of SP and CGRP fibers within the
epithelium of the upper laryngeal mucosa is a
predominant feature of hypoxic adaptation, and this may
be involved in airway protection, swallowing, and other
functions in the chronically hypoxic environment. In
addition, the increased SP and CGRP fibers around the
laryngeal gland suggest an enhanced mucous secretion,
and this may participate in the airway defense
mechanism in low O2 conditions.
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