Publication:
Farnesoid X receptor: a potential therapeutic target in multiple organs

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Zhang-35-1403-1414-2020.pdf(1.18 MB)
Date
2020
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Authors
Zhang, Chao ; Wang, Zixuan ; Feng, Qingqing ; Chen, Wei-Dong ; Wang, Yan-Dong
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-301
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info:eu-repo/semantics/article
Description
Abstract
Farnesoid X receptor (FXR), a member of the nuclear receptor family, is a common receptor found in the intestine and liver, and helps to maintain systemic metabolic homeostasis through regulating bile acid, glucose, lipid metabolism, and energy homeostatsis. In addition, FXR regulates the functions of various organs, such as liver, intestine, kidney, breast, pancreas, cardiovascular system and brain. FXR also plays a key role in regulation of gut-microbiota through mediating the various signaling pathways. Accordingly, FXR has become an attractive therapeutic target in a variety of diseases. This review combines classical and recent research reports to introduce the basic information about FXR and its important roles in various organs of the body.
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Farnesoid X receptor , Bile acid , Metabolic homeostasis , Signaling pathways
Citation
Histology and Histopathology Vol. 35, nº12 (2020)
URI
http://hdl.handle.net/10201/126587
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Histology and histopathology Vol.35,nº12 (2020)
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