Publication: Effects of cigarette smoke exposure on the utlrastructure of the golden hamster parathyroid gland
Authors
Yano, R. ; Hayakawa, D. ; Emura, S. ; chen, H. ; Ozawa, Y. ; Taguchi, H. ; Shoumura, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cigarette smoking has been identified as one
of the risk factors to induce osteoporosis. However, we
find no study on the morphology of the parathy r o i d
gland under smoking exposure. We studied the
ultrastructure of the parathyroid gland, lung and femur
of the golden hamster exposed to cigarette smoke. Fourweek-
old male hamsters were housed in a plastic case
(48x31x30 cm) and were exposed to cigarette smoke for
12 weeks, 5 minutes exposure, 4 times a day, 4 days a
week. There were no differences in serum calcium level
and the whole bone mineral density between the control
and the smoke-exposed groups. In the parathyroid gland
of the smoke - exposed animals, the Golgi complexe s
associated with many prosecretory granules were well
d eveloped and many secretory granules were located
near the plasma membrane. Large lipid-like inclusion
bodies were observed in the alveolar macrophages of the
smoke-exposed animals. The femur morphology showed
a wider area of resorbing surface in the smoke-exposed
group than in the control group. From these findings, it
is conceivable that the secretory activity of the
p a r a t hyroid gland was stimulated with cigarette smoke
exposure.
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