Publication: Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development
Authors
Logothetidou, Anastasia ; Vandecasteele, Tim ; Van Mulken, Els ; Vandevelde, Kimberley ; Cornillie, Pieter
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-850
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info:eu-repo/semantics/article
Description
Abstract
Intussusceptive angiogenesis (IA) is required
for normal embryonic vascular development. The Tie
family of receptors and their ligands, the angiopoietins,
play an important role in the growth or regression of
blood vessels which are important not only during
development but also throughout an organism’s life. The
presence of IA was investigated in glomerular capillaries
of the fetal porcine metanephros using Mercox II resin
casts. The first signs of IA were observed in stage III
glomeruli. Stage IV and V glomeruli showed numerous
signs of aligned pillar formation and their successive
merging to delineate the vascular entities. Furthermore,
immunohistochemistry was used to determine the exact
locations of the Tie receptors in the developing porcine
metanephric kidneys. Tie1 and Tie2 were found in
endothelial cells of all glomeruli. Strong expression of
the receptors was found in podocytes of stage V
glomeruli whereas a weaker expression was observed in
the cuboidal epithelial cells of stage III and IV
glomeruli. Remarkably, the receptors were also found in
the parietal epithelium of Bowman’s capsule. These
findings indicate that there might be an association
between Tie receptors and IA during porcine
metanephric development and during glomerulogenesis
in particular.
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Citation
Histology and Histopathology, Vol.32, nº8, (2017)
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