Browsing by Subject "Glomerulus"

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    Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Logothetidou, Anastasia; Vandecasteele, Tim; Van Mulken, Els; Vandevelde, Kimberley; Cornillie, Pieter
    Intussusceptive angiogenesis (IA) is required for normal embryonic vascular development. The Tie family of receptors and their ligands, the angiopoietins, play an important role in the growth or regression of blood vessels which are important not only during development but also throughout an organism’s life. The presence of IA was investigated in glomerular capillaries of the fetal porcine metanephros using Mercox II resin casts. The first signs of IA were observed in stage III glomeruli. Stage IV and V glomeruli showed numerous signs of aligned pillar formation and their successive merging to delineate the vascular entities. Furthermore, immunohistochemistry was used to determine the exact locations of the Tie receptors in the developing porcine metanephric kidneys. Tie1 and Tie2 were found in endothelial cells of all glomeruli. Strong expression of the receptors was found in podocytes of stage V glomeruli whereas a weaker expression was observed in the cuboidal epithelial cells of stage III and IV glomeruli. Remarkably, the receptors were also found in the parietal epithelium of Bowman’s capsule. These findings indicate that there might be an association between Tie receptors and IA during porcine metanephric development and during glomerulogenesis in particular.
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    The glomerular peripolar cell: a review
    (Murcia : F. Hernández, 1991) Gardiner, D.S.; Downie, I.; Gibson, I.W.; More, I.A.R.; Lindop, G.B.M.
    There is now morphological evidence from several species that the peripolar cell is a distinctive glomerular cell which may have a secretory function, although a secretory product has not been identified. Peripolar cells, like other glomerular epithelial cells, probably absorb plasma proteins from the glomerular filtrate. Peripolar cells may participate in regulation of sodium balance and the changes in renal function which occur at the time of birth. They are ideally situated to monitor the composition of the glomerular filtrate andlor the calibre of the glomerular arterioles. The relationship between pcripolar cells and other granulated glomerular epithelial cells must be clarified, however their morphology and unique anatomical site is suggestive of a specialised function.