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Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex

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dc.contributor.authorHochol, A.es
dc.contributor.authorMarkowska, A.es
dc.contributor.authorMeneghelli, V.
dc.contributor.authorJedrzejczak, N.
dc.contributor.authorMajchrzak, M.
dc.contributor.authorNowak, M.
dc.contributor.authorNussdorfer, G.G.
dc.contributor.authorMalendowicz, L.K.
dc.date.accessioned2011-02-22T11:09:58Z
dc.date.available2011-02-22T11:09:58Z
dc.date.issued1999
dc.description.abstractNeurotensin (NT) and bombesin (BM)-like peptides are known to be involved in the regulation of the rat hypothalamo-pituitary-adrenal axis. By using selective NT- and BM-receptor antagonists (NT-A and BM-A, respectively) we investigated whether endogenous NT and BM-like peptides play a role in the control of rat adrenal secretion and growth during enucleation-induced regeneration. At day 5 of regeneration, NT-A did not affect the plasma concentrations of aldosterone (PAC) and corticosterone (PBC), but at day 8, it raised both PAC and PBC over the respective baseline value; the simultaneous administration of NT abolished this effect of NT-A. BMA did not alter PAC and PBC at day 5 of regeneration, while at day 8 it enhanced PBC, an effect reversed by BM. NT-A did not alter mitotic index, and BM-A lowered it at both day 5 and day 8 of regeneration, an effect suppressed by the simultaneous administration of BM. Collectively, these findings allow us to draw the following conclusions: 1) endogenous NT and BM-like peptides influence adrenocortical regeneration in rats; 2) NT exerts a tonic inhibitory action on both aldosterone and corticosterone secretion, without affecting cellproliferation rate; and 3) BM-like peptides exert a tonic suppressive effect on corticosterone production, coupled with a clear-cut stimulating effect on cell proliferation.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19240
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeurotensines
dc.subjectRates
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEffects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortexes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 4 (1999)