Publication: Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex
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Date
1999
Authors
Hochol, A. ; Markowska, A. ; Meneghelli, V. ; Jedrzejczak, N. ; Majchrzak, M. ; Nowak, M. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neurotensin (NT) and bombesin (BM)-like
peptides are known to be involved in the regulation of
the rat hypothalamo-pituitary-adrenal axis. By using
selective NT- and BM-receptor antagonists (NT-A and
BM-A, respectively) we investigated whether endogenous
NT and BM-like peptides play a role in the
control of rat adrenal secretion and growth during
enucleation-induced regeneration. At day 5 of
regeneration, NT-A did not affect the plasma
concentrations of aldosterone (PAC) and corticosterone
(PBC), but at day 8, it raised both PAC and PBC over
the respective baseline value; the simultaneous
administration of NT abolished this effect of NT-A. BMA
did not alter PAC and PBC at day 5 of regeneration,
while at day 8 it enhanced PBC, an effect reversed by
BM. NT-A did not alter mitotic index, and BM-A
lowered it at both day 5 and day 8 of regeneration, an
effect suppressed by the simultaneous administration of
BM. Collectively, these findings allow us to draw the
following conclusions: 1) endogenous NT and BM-like
peptides influence adrenocortical regeneration in rats; 2)
NT exerts a tonic inhibitory action on both aldosterone
and corticosterone secretion, without affecting cellproliferation
rate; and 3) BM-like peptides exert a tonic
suppressive effect on corticosterone production, coupled
with a clear-cut stimulating effect on cell proliferation.
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