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Paracrine role for TGF-ß-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular disease

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dc.contributor.authorSoon Lee, Hyun
dc.date.accessioned2017-09-08T18:02:31Z
dc.date.available2017-09-08T18:02:31Z
dc.date.issued2012
dc.description.abstractTransforming growth factor-ß (TGF-ß) is a key regulator of extracellular matrix (ECM), and may mediate the development of glomerulosclerosis with accumulation of mesangial matrix. Mesangial cells secrete TGF-ß in response to common in vitro fibrogenic stimuli. Yet mesangial immunostaining for active TGF-ß1 is frequently negative in chronic glomerular disease. TGF-ß is rather expressed and/or activated by podocytes in both mesangial and podocyte diseases. Activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor (CTGF or CCN2) and vascular endothelial growth factor (VEGF) expression. Podocyte CTGF seems to have paracrine effects on mesangial cells to stimulate CTGF expression. CTGF appears to stimulate the fibronectin-matrix assembly via enhanced cell-surface expression of α5ß1 integrin in the mesangium of diseased glomeruli. Podocyte VEGF-A overexpression also seems to play a paracrine role on mesangial cells to upregulate VEGF/VEGF receptor systems and to overproduce matrix proteins. Thus, paracrine CTGF and VEGF may contribute to mesangial matrix accumulation in chronic glomerular disease, culminating in the development of glomerulosclerosis. Together, these data bring new mechanistic insights into our understanding of the pathogenic role of TGF-ß-induced CTGF and VEGF in mesangial matrix expansion in chronic progressive glomerular diseasees
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 9 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54118
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectFibronectines
dc.subjectMesangial matrixes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleParacrine role for TGF-ß-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 9 (2012)