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Microenvironment in breast tumorigenesis: Friend or foe?

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dc.contributor.authorMartins, Diana
dc.contributor.authorSchmitt, Fernando
dc.date.accessioned2022-06-03T09:04:56Z
dc.date.available2022-06-03T09:04:56Z
dc.date.issued2019
dc.description.abstractIt is now widely accepted that the tumor microenvironment is a pathologically active niche that shapes tumor nature, evolution and response to treatment. Close interactions between cancer cells and stroma are known to regulate several cancer pathways and thus the determination of different tumor-stromal interactions could be an important step in invasiveness. The breast cancer microenvironment is a complex combination of several different cell types and molecules and a key contributor to tumor development and progression. The microenvironment includes fibroblasts, macrophages, immune cells, tumor-infiltrating lymphocytes, endothelial cells and angiogenic vascular cells, whereas stromal cells surround and interact with tumor cells. Recent data demonstrate significant gene expression alterations in microenvironment cells during disease progression and several stromal cell types are implicated in promoting the “hallmarks of cancer”, which can be explored as targets for cancer therapy. Besides identifying new therapeutic targets, the microenvironment has also been implicated in chemotherapy resistance, suggesting that the crosstalk between cancer and its microenvironment is a promising strategy to target breast cancer.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.34, nº1, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-021
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/120936
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBreast canceres
dc.subjectTumor stromaes
dc.subjectMicroenvironmentes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMicroenvironment in breast tumorigenesis: Friend or foe?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº1 (2019)