Publication: Microenvironment in breast tumorigenesis: Friend or foe?
Authors
Martins, Diana ; Schmitt, Fernando
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-021
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info:eu-repo/semantics/article
Description
Abstract
It is now widely accepted that the tumor
microenvironment is a pathologically active niche that
shapes tumor nature, evolution and response to
treatment. Close interactions between cancer cells and
stroma are known to regulate several cancer pathways
and thus the determination of different tumor-stromal
interactions could be an important step in invasiveness.
The breast cancer microenvironment is a complex
combination of several different cell types and molecules
and a key contributor to tumor development and
progression. The microenvironment includes fibroblasts,
macrophages, immune cells, tumor-infiltrating
lymphocytes, endothelial cells and angiogenic vascular
cells, whereas stromal cells surround and interact with
tumor cells. Recent data demonstrate significant gene
expression alterations in microenvironment cells during
disease progression and several stromal cell types are
implicated in promoting the “hallmarks of cancer”,
which can be explored as targets for cancer therapy.
Besides identifying new therapeutic targets, the
microenvironment has also been implicated in
chemotherapy resistance, suggesting that the crosstalk
between cancer and its microenvironment is a promising
strategy to target breast cancer.
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Citation
Histology and Histopathology, Vol.34, nº1, (2019)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/